ノバルティスのインスタグラム(novartis) - 12月18日 00時07分

A cryo-electron microscope, like this one, takes thousands of images of samples cooled to very low temperatures. The imagery obtained this way can be used to identify structural details of large proteins, or protein complexes, like never before. Called cryo-EM for short, this cutting-edge imaging method allows researchers to visualize complicated cellular machines such as ribosomes at a near-atomic resolution (up to x60,000 their original size), and was even awarded the 2017 #NobelPrize in chemistry.
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Scientists from the Novartis Institutes for BioMedical Research and the Friedrich Miescher Institute (@fmiscience) in Basel, Switzerland, teamed up to use cryo-EM to try to better understand the biology of therapeutic targets and to advance drug discovery. They are now able to generate 3D, high-resolution models of targets, so-called density maps, which considerably simplify the search for suitable treatment methods in certain diseases and open up new possibilities to improve and extend people’s lives.

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