ノバルティスのインスタグラム(novartis) - 12月12日 02時50分

Some targets evade drug hunters for decades. These molecules dodge their pursuers time and again, draining precious resources. Take phosphatases, proteins that play an important role in many cell signaling pathways. NIBR researchers recently caught one of the phosphatases, using an outside-the-box approach to block SHP2 (pictured here), a target involved in many cancers. They identified several compounds that silence the protein by cementing it shut. The team went on to show that this molecular “glue” kills human #cancer cells in mice. The tumor-fighting “glue” is now being optimized for testing in patients. #ReimagineMedicine #FightCancer

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