ノバルティスのインスタグラム(novartis) - 4月4日 22時13分

DNA-encoded libraries are created by combining groups of chemical building blocks together into larger compounds. Every building block or combination of blocks has a unique barcode. Rather than a series of parallel lines (like a standard barcode on a paper label), the barcodes are strands of unique DNA sequences. The libraries provide a fast and accurate way for scientists to find compounds that bind to cancer targets. The process involves adding the protein target of interest to a test tube containing the DNA-encoded library. Researchers find “hits” by rinsing away any compounds that don't bind efficiently to the target. They then "read" the barcodes of the remaining bound compounds using DNA sequencing, homing in on a rare hit that could one day be the basis for a new #cancer therapy. #AACR18

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